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Xu Shi-Wen Selected Research

Pulmonary Fibrosis (Fibrosing Alveolitis)

8/2013Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease.
9/2007A polymorphism in the CTGF promoter region associated with systemic sclerosis.
7/2006Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
11/2004Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
6/2004Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

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Xu Shi-Wen Research Topics

Disease

13Fibrosis (Cirrhosis)
08/2019 - 11/2004
10Systemic Scleroderma (Systemic Sclerosis)
09/2016 - 06/2004
5Pulmonary Fibrosis (Fibrosing Alveolitis)
08/2013 - 06/2004
4Wounds and Injuries (Trauma)
08/2019 - 01/2007
4Cicatrix (Scar)
04/2008 - 06/2004
3Neoplasms (Cancer)
08/2013 - 04/2008
2Diffuse Scleroderma (Progressive Systemic Sclerosis)
03/2021 - 08/2019
2Peripheral Arterial Disease
01/2012 - 06/2011
1Idiopathic Pulmonary Fibrosis
09/2016
1Interstitial Lung Diseases (Interstitial Lung Disease)
08/2013
1Colorectal Neoplasms (Colorectal Cancer)
03/2012
1Colonic Neoplasms (Colon Cancer)
03/2012
1Erectile Dysfunction
09/2011
1Atherosclerosis
06/2011
1Inflammation (Inflammations)
01/2011
1Hypoxia (Hypoxemia)
06/2009
1Chronic Disease (Chronic Diseases)
10/2007
1Autoimmune Diseases (Autoimmune Disease)
09/2007
1Thrombosis (Thrombus)
09/2005

Drug/Important Bio-Agent (IBA)

5CollagenIBA
03/2021 - 06/2004
5Transforming Growth Factor beta (TGF-beta)IBA
05/2010 - 11/2004
4Proteins (Proteins, Gene)FDA Link
08/2019 - 06/2004
4Transforming Growth Factors (Transforming Growth Factor)IBA
09/2016 - 03/2011
4Endothelin-1 (Endothelin 1)IBA
03/2012 - 07/2006
4Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2012 - 09/2005
4Connective Tissue Growth FactorIBA
05/2010 - 12/2004
3Bleomycin (Blenoxane)FDA LinkGeneric
08/2019 - 01/2011
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2015 - 12/2005
2alpha2 Subunit Collagen Type IIBA
09/2016 - 09/2016
2CytokinesIBA
09/2016 - 11/2004
2Protein Isoforms (Isoforms)IBA
09/2016 - 09/2016
2Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
01/2015 - 03/2011
2Thrombospondin 1IBA
01/2015 - 03/2011
2Extracellular Matrix ProteinsIBA
08/2013 - 10/2007
2OligonucleotidesIBA
08/2013 - 11/2004
1Verteporfin (Visudyne)FDA Link
03/2021
1Cysteine-Rich Protein 61IBA
08/2019
1CateninsIBA
09/2016
1InterferonsIBA
08/2013
1LigandsIBA
11/2012
1Focal Adhesion Protein-Tyrosine KinasesIBA
05/2012
1N- methyl- N- (3- ((2- (2- oxo- 2,3- dihydro- 1H- indol- 5- ylamino)- 5- trifluoromethyl- pyrimidin- 4- ylamino)- methyl)- pyridin- 2- yl)- methanesulfonamideIBA
05/2012
1Small Interfering RNA (siRNA)IBA
05/2012
1Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
09/2011
1EndoglinIBA
08/2011
1indium-bleomycinIBA
01/2011
1Collagen Type I (Type I Collagen)IBA
11/2010
1Fibronectins (Fibronectin)IBA
11/2010
1epigallocatechin gallate (epigallocatechin-3-gallate)IBA
11/2010
1AntioxidantsIBA
11/2010
1Biological ProductsIBA
05/2010
1GlucocorticoidsIBA
06/2009
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2009
1Angiotensin IIIBA
06/2009
1Protein Kinases (Protein Kinase)IBA
10/2008
1AutoantibodiesIBA
09/2007
1anti-scl-70 autoantibodiesIBA
09/2007
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
01/2007
1A-factor (Streptomyces)IBA
01/2007
1JNK Mitogen-Activated Protein KinasesIBA
07/2006
1Endothelins (Endothelin)IBA
07/2006
1Activins (Activin)IBA
12/2005
1Phosphotransferases (Kinase)IBA
12/2005
1Proteoglycans (Proteoglycan)IBA
12/2005
1Heparitin Sulfate (Heparan Sulfate)IBA
12/2005
1Syndecan-4IBA
12/2005
1Vasodilator Agents (Vasodilators)IBA
09/2005
1Angiotensin Receptors (Angiotensin II Receptor)IBA
11/2004
1PaxillinIBA
06/2004
1Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
06/2004
1ezrinIBA
06/2004
1moesinIBA
06/2004

Therapy/Procedure

1Therapeutics
03/2012